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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Alpha-1D adrenergic receptor | ||
| Ligand | BDBM50211343 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_444278 (CHEMBL894518) | ||
| Ki | 3.3±n/a nM | ||
| Citation |  Chiu, G; Li, S; Connolly, PJ; Pulito, V; Liu, J; Middleton, SA (Arylpiperazinyl)cyclohexylsufonamides: discovery of alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS). Bioorg Med Chem Lett17:3292-7 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Alpha-1D adrenergic receptor | |||
| Name: | Alpha-1D adrenergic receptor | ||
| Synonyms: | ADA1D_HUMAN | ADRA1A | ADRA1D | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1D-adrenoceptor | Alpha 1D-adrenoreceptor | Alpha adrenergic receptor (1a and 1d) | Alpha-1D adrenoceptor | Alpha-adrenergic receptor 1a | adrenergic Alpha1D | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 60485.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | adrenergic Alpha1D ADRA1D HUMAN::P25100 | ||
| Residue: | 572 | ||
| Sequence: |
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| BDBM50211343 | |||
| n/a | |||
| Name | BDBM50211343 | ||
| Synonyms: | 3-fluoro-N-((1s,4s)-4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide | CHEMBL232779 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H34FN3O3S | ||
| Mol. Mass. | 475.619 | ||
| SMILES | CC(C)Oc1ccccc1N1CCN(CC1)[C@@H]1CC[C@@H](CC1)NS(=O)(=O)c1cccc(F)c1 |wU:16.17,19.24,(-6.39,4.8,;-7.18,3.48,;-8.72,3.5,;-6.42,2.13,;-7.21,.81,;-8.75,.83,;-9.53,-.5,;-8.77,-1.84,;-7.24,-1.85,;-6.46,-.53,;-4.93,-.55,;-4.16,-1.89,;-2.62,-1.91,;-1.85,-.59,;-2.59,.75,;-4.13,.77,;-.31,-.61,;.44,-1.95,;1.97,-1.98,;2.77,-.65,;2.01,.69,;.47,.72,;4.32,-.69,;5.1,.64,;3.77,1.42,;6.42,-.12,;5.86,1.98,;5.08,3.3,;5.83,4.64,;7.38,4.66,;8.16,3.33,;9.7,3.34,;7.4,1.99,)| | ||
| Structure | 
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