Reaction Details | |||
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Target | Alpha-1A adrenergic receptor | ||
Ligand | BDBM50211335 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_444276 (CHEMBL894516) | ||
Ki | 3±n/a nM | ||
Citation | Chiu, G; Li, S; Connolly, PJ; Pulito, V; Liu, J; Middleton, SA (Arylpiperazinyl)cyclohexylsufonamides: discovery of alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS). Bioorg Med Chem Lett17:3292-7 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Alpha-1A adrenergic receptor | |||
Name: | Alpha-1A adrenergic receptor | ||
Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C | ||
Type: | Cell-surface receptors | ||
Mol. Mass.: | 51511.67 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35348 | ||
Residue: | 466 | ||
Sequence: |
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BDBM50211335 | |||
n/a | |||
Name | BDBM50211335 | ||
Synonyms: | 4-chloro-2-fluoro-N-((1r,4r)-4-(4-(2-isopropoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide | CHEMBL233582 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H33ClFN3O3S | ||
Mol. Mass. | 510.064 | ||
SMILES | CC(C)Oc1ccccc1N1CCN(CC1)[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc(Cl)cc1F |wU:16.17,wD:19.24,(14.29,-4.12,;13.51,-5.45,;11.97,-5.43,;14.26,-6.79,;13.48,-8.12,;11.94,-8.1,;11.15,-9.42,;11.92,-10.77,;13.45,-10.78,;14.23,-9.46,;15.76,-9.48,;16.53,-10.82,;18.06,-10.84,;18.84,-9.51,;18.1,-8.18,;16.56,-8.16,;20.38,-9.54,;21.16,-8.21,;22.7,-8.23,;23.45,-9.58,;22.66,-10.9,;21.13,-10.88,;25.01,-9.61,;25.79,-8.28,;24.46,-7.5,;27.11,-9.05,;26.54,-6.94,;25.77,-5.62,;26.52,-4.28,;28.07,-4.26,;28.83,-2.92,;28.85,-5.59,;28.09,-6.93,;28.87,-8.26,)| | ||
Structure |