Reaction Details | |||
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Target | D(3) dopamine receptor | ||
Ligand | BDBM50219939 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_449063 (CHEMBL898268) | ||
IC50 | 0.2±n/a nM | ||
Citation | Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett17:5340-4 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
D(3) dopamine receptor | |||
Name: | D(3) dopamine receptor | ||
Synonyms: | DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3 | ||
Type: | Protein | ||
Mol. Mass.: | 49540.58 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | P19020 | ||
Residue: | 446 | ||
Sequence: |
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BDBM50219939 | |||
n/a | |||
Name | BDBM50219939 | ||
Synonyms: | CHEMBL240693 | N-((1r,4r)-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)pyridine-3-sulfonamide | ||
Type | Small organic molecule | ||
Emp. Form. | C23H30Cl2N4O2S | ||
Mol. Mass. | 497.481 | ||
SMILES | Clc1cccc(N2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3cccnc3)CC2)c1Cl |wU:15.18,wD:12.11,(14.57,-10.28,;13.25,-9.5,;13.25,-7.96,;11.92,-7.19,;10.58,-7.96,;10.59,-9.49,;9.26,-10.25,;9.25,-11.79,;7.92,-12.55,;6.58,-11.78,;5.26,-12.55,;3.92,-11.78,;2.59,-12.55,;1.25,-11.78,;-.09,-12.55,;-.09,-14.1,;1.25,-14.87,;2.59,-14.1,;-1.42,-14.9,;-2.77,-14.14,;-3.53,-15.48,;-2,-12.8,;-4.1,-13.37,;-5.44,-14.14,;-6.77,-13.38,;-6.78,-11.83,;-5.43,-11.05,;-4.1,-11.83,;6.58,-10.25,;7.92,-9.48,;11.92,-10.27,;11.9,-11.81,)| | ||
Structure |