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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 4 | ||
| Ligand | BDBM50221966 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_449743 (CHEMBL898850) | ||
| IC50 | 12±n/a nM | ||
| Citation |  Kaelin, DE; Smenton, AL; Eiermann, GJ; He, H; Leiting, B; Lyons, KA; Patel, RA; Patel, SB; Petrov, A; Scapin, G; Wu, JK; Thornberry, NA; Weber, AE; Duffy, JL 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem Lett17:5806-11 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 4 | |||
| Name: | Dipeptidyl peptidase 4 | ||
| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 88271.01 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27487 | ||
| Residue: | 766 | ||
| Sequence: |
| ||
| BDBM50221966 | |||
| n/a | |||
| Name | BDBM50221966 | ||
| Synonyms: | (2S,3S)-2-amino-1-((S)-3-fluoro-3-methylpyrrolidin-1-yl)-3-(4-(4-fluorophenyl)cyclohexyl)butan-1-one | CHEMBL392524 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H30F2N2O | ||
| Mol. Mass. | 364.4725 | ||
| SMILES | C[C@H]([C@H](N)C(=O)N1CC[C@](C)(F)C1)C1CCC(CC1)c1ccc(F)cc1 |wU:9.9,2.2,wD:1.0,9.10,(-.16,4.94,;-.16,3.4,;1.18,2.63,;1.18,1.09,;2.51,3.4,;2.51,4.94,;3.86,2.63,;5.25,3.25,;6.28,2.1,;5.51,.77,;7.01,.45,;4.72,-.56,;4,1.09,;-1.5,2.63,;-1.5,1.08,;-2.82,.32,;-4.16,1.08,;-4.16,2.63,;-2.83,3.4,;-5.49,.31,;-6.82,1.08,;-8.15,.31,;-8.15,-1.23,;-9.48,-2.01,;-6.81,-2,;-5.48,-1.23,)| | ||
| Structure | 
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