| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM50227507 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_461583 (CHEMBL927606) |
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| Ki | 21000±n/a nM |
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| Citation |  Grunewald, GL; Seim, MR; Bhat, SR; Wilson, ME; Criscione, KR Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase. Bioorg Med Chem16:542-59 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 30852.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 282 |
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| Sequence: | MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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| BDBM50227507 |
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| n/a |
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| Name | BDBM50227507 |
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| Synonyms: | 2-bromo-6-(trifluoromethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | CHEMBL253219 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H7BrF3NS |
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| Mol. Mass. | 286.112 |
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| SMILES | FC(F)(F)C1Cc2sc(Br)cc2CN1 |w:4.3| |
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| Structure | 
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