| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stromelysin-1 |
|---|
| Ligand | BDBM50227735 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_459991 (CHEMBL944034) |
|---|
| IC50 | 378±n/a nM |
|---|
| Citation |  Whitlock, GA; Dack, KN; Dickinson, RP; Lewis, ML A novel series of highly selective inhibitors of MMP-3. Bioorg Med Chem Lett17:6750-3 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stromelysin-1 |
|---|
| Name: | Stromelysin-1 |
|---|
| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53973.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08254 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
|
|
|
|---|
| BDBM50227735 |
|---|
| n/a |
|---|
| Name | BDBM50227735 |
|---|
| Synonyms: | 2-(biphenyl-4-ylmethyl-methyl-sulfamoyl)-N-hydroxy-acetamide | CHEMBL254191 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H18N2O4S |
|---|
| Mol. Mass. | 334.39 |
|---|
| SMILES | CN(Cc1ccc(cc1)-c1ccccc1)S(=O)(=O)CC(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
