Reaction Details |
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Target | Cholinesterase |
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Ligand | BDBM50228385 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_452432 (CHEMBL902668) |
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IC50 | 35.1±n/a nM |
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Citation | Bolognesi, ML; Cavalli, A; Valgimigli, L; Bartolini, M; Rosini, M; Andrisano, V; Recanatini, M; Melchiorre, C Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease. J Med Chem50:6446-9 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholinesterase |
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Name: | Cholinesterase |
Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
Type: | Homotetramer |
Mol. Mass.: | 68422.27 |
Organism: | Homo sapiens (Human) |
Description: | P06276 |
Residue: | 602 |
Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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BDBM50228385 |
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n/a |
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Name | BDBM50228385 |
Synonyms: | CHEMBL235014 | N-(2-(2-(2-(5,6,7,8-tetrahydroacridin-9-ylamino)ethoxy)ethoxy)ethyl)-5,6,7,8-tetrahydroacridin-9-amine |
Type | Small organic molecule |
Emp. Form. | C32H38N4O2 |
Mol. Mass. | 510.6697 |
SMILES | C(COCCOCCNc1c2CCCCc2nc2ccccc12)Nc1c2CCCCc2nc2ccccc12 |
Structure |
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