| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
|---|
| Ligand | BDBM50220067 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_530558 (CHEMBL968469) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Conchon, E; Anizon, F; Aboab, B; Golsteyn, RM; Léonce, S; Pfeiffer, B; Prudhomme, M Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone. Eur J Med Chem43:282-92 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Chk1 |
|---|
| Name: | Serine/threonine-protein kinase Chk1 |
|---|
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 54443.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_166295192 |
|---|
| Residue: | 476 |
|---|
| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
|
|
|
|---|
| BDBM50220067 |
|---|
| n/a |
|---|
| Name | BDBM50220067 |
|---|
| Synonyms: | 11H-2,5,11-triaza-benzo[a]trindene-1,3,4,6-tetraone | CHEMBL388648 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H7N3O4 |
|---|
| Mol. Mass. | 305.2445 |
|---|
| SMILES | O=c1[nH]c(=O)c2c1c1[nH]c3ccccc3c1c1c2c(=O)[nH]c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
