Reaction Details | |||
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Target | Sodium-dependent serotonin transporter | ||
Ligand | BDBM50252222 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_487557 (CHEMBL1013151) | ||
Ki | 20±n/a nM | ||
Citation | Zhou, D; Zhou, P; Evrard, DA; Meagher, K; Webb, M; Harrison, BL; Huryn, DM; Golembieski, J; Hornby, GA; Schechter, LE; Smith, DL; Andree, TH; Mewshaw, RE Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives. Bioorg Med Chem16:6707-23 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium-dependent serotonin transporter | |||
Name: | Sodium-dependent serotonin transporter | ||
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 70168.43 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | P31652 | ||
Residue: | 630 | ||
Sequence: |
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BDBM50252222 | |||
n/a | |||
Name | BDBM50252222 | ||
Synonyms: | 3-[(1,4-trans)-4-(4-Quinolin-8-yl-piperazin-1-yl)-cyclohexyl]-1H-indole-5-carbonitrile | CHEMBL481914 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H29N5 | ||
Mol. Mass. | 435.5634 | ||
SMILES | N#Cc1ccc2[nH]cc([C@H]3CC[C@@H](CC3)N3CCN(CC3)c3cccc4cccnc34)c2c1 |r,wU:12.15,wD:9.8,(34.65,-31.84,;35.06,-33.34,;35.37,-34.85,;36.83,-35.34,;37.13,-36.85,;35.98,-37.86,;35.96,-39.4,;34.49,-39.86,;33.6,-38.61,;32.06,-38.59,;31.3,-37.25,;29.76,-37.23,;28.98,-38.56,;29.74,-39.91,;31.27,-39.92,;27.44,-38.55,;26.67,-39.88,;25.13,-39.87,;24.37,-38.54,;25.14,-37.21,;26.68,-37.21,;22.83,-38.53,;22.06,-39.86,;20.52,-39.86,;19.75,-38.51,;20.53,-37.18,;19.77,-35.86,;20.54,-34.53,;22.08,-34.54,;22.84,-35.87,;22.06,-37.2,;34.52,-37.37,;34.22,-35.86,)| | ||
Structure |