Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium-dependent serotonin transporter | ||
| Ligand | BDBM50252178 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_487557 (CHEMBL1013151) | ||
| Ki | 13.8±n/a nM | ||
| Citation |  Zhou, D; Zhou, P; Evrard, DA; Meagher, K; Webb, M; Harrison, BL; Huryn, DM; Golembieski, J; Hornby, GA; Schechter, LE; Smith, DL; Andree, TH; Mewshaw, RE Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives. Bioorg Med Chem16:6707-23 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium-dependent serotonin transporter | |||
| Name: | Sodium-dependent serotonin transporter | ||
| Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 70168.43 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | P31652 | ||
| Residue: | 630 | ||
| Sequence: |
| ||
| BDBM50252178 | |||
| n/a | |||
| Name | BDBM50252178 | ||
| Synonyms: | 5-{4-[(1,4-cis)-4-(5-Fluoro-1H-indol-3-yl)-cyclohexyl]-piperazin-1-yl}-quinoline | CHEMBL481108 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H29FN4 | ||
| Mol. Mass. | 428.5444 | ||
| SMILES | Fc1ccc2[nH]cc([C@@H]3CC[C@@H](CC3)N3CCN(CC3)c3cccc4ncccc34)c2c1 |r,wU:8.7,11.14,(15.69,-14.56,;15.99,-16.07,;17.46,-16.56,;17.76,-18.07,;16.6,-19.08,;16.59,-20.62,;15.12,-21.08,;14.23,-19.83,;12.69,-19.81,;11.93,-18.47,;10.38,-18.45,;9.61,-19.78,;10.37,-21.12,;11.9,-21.14,;8.07,-19.77,;7.29,-21.1,;5.75,-21.09,;5,-19.76,;5.77,-18.43,;7.31,-18.43,;3.45,-19.75,;2.69,-21.08,;1.15,-21.08,;.38,-19.73,;1.16,-18.4,;.4,-17.08,;1.17,-15.75,;2.71,-15.76,;3.47,-17.09,;2.69,-18.41,;15.15,-18.59,;14.84,-17.08,)| | ||
| Structure | 
| ||