Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 1A

Ligand

BDBM50252082

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_487560 (CHEMBL1013154)

13±n/a nM

Citation

Zhou, D; Zhou, P; Evrard, DA; Meagher, K; Webb, M; Harrison, BL; Huryn, DM; Golembieski, J; Hornby, GA; Schechter, LE; Smith, DL; Andree, TH; Mewshaw, RE Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives. Bioorg Med Chem16:6707-23 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 1A

Name:

5-hydroxytryptamine receptor 1A

Synonyms:

Type:

n/a

Mol. Mass.:

46122.49

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

422

Sequence:

MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ

BDBM50252082

n/a

Name

BDBM50252082

Synonyms:

3-[trans-4-[4-(1H-Indol-4-yl)-1-pipera-zinyl]-cyclohexyl]-2-methyl-1H-indole | CHEMBL479782

Type

Small organic molecule

Emp. Form.

C27H32N4

Mol. Mass.

412.5698

SMILES

Cc1[nH]c2ccccc2c1[C@H]1CC[C@@H](CC1)N1CCN(CC1)c1cccc2[nH]ccc12 |r,wU:10.11,wD:13.18,(-8.67,-34.74,;-8.21,-36.21,;-6.75,-36.7,;-6.76,-38.24,;-5.64,-39.27,;-5.98,-40.76,;-7.44,-41.22,;-8.57,-40.18,;-8.23,-38.69,;-9.13,-37.44,;-10.66,-37.43,;-11.45,-38.75,;-12.99,-38.74,;-13.75,-37.4,;-12.97,-36.07,;-11.42,-36.09,;-15.28,-37.39,;-16.06,-38.72,;-17.6,-38.7,;-18.35,-37.37,;-17.57,-36.04,;-16.04,-36.04,;-19.89,-37.37,;-20.66,-36.03,;-22.18,-36.02,;-22.97,-37.35,;-22.21,-38.7,;-22.69,-40.17,;-21.43,-41.07,;-20.18,-40.16,;-20.66,-38.69,)|

Structure