| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 3A43 |
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| Ligand | BDBM50252659 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_487752 (CHEMBL1009484) |
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| IC50 | 1900±n/a nM |
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| Citation |  Jin, J; An, M; Sapienza, A; Aiyar, N; Naselsky, D; Sarau, HM; Foley, JJ; Salyers, KL; Knight, SD; Keenan, RM; Rivero, RA; Dhanak, D; Douglas, SA Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides. Bioorg Med Chem Lett18:3950-4 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 3A43 |
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| Name: | Cytochrome P450 3A43 |
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| Synonyms: | CP343_HUMAN | CYP3A43 | Cytochrome P450 3A | Cytochrome P450 3A43 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57676.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_487752 |
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| Residue: | 503 |
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| Sequence: | MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS
KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL
PILQPEKPIVLKVHLRDGITSGP
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| BDBM50252659 |
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| n/a |
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| Name | BDBM50252659 |
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| Synonyms: | (S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrrolidin-3-yl)-3,4-dichlorobenzamide | CHEMBL495075 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26BrCl2N3O2 |
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| Mol. Mass. | 527.281 |
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| SMILES | Clc1ccc(cc1Cl)C(=O)N[C@H]1CCN(Cc2ccc(OC3CCNCC3)c(Br)c2)C1 |r| |
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| Structure | 
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