| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 2 |
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| Ligand | BDBM50251758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_488664 (CHEMBL988354) |
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| IC50 | 96±n/a nM |
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| Citation |  Sattigeri, JA; Andappan, MM; Kishore, K; Thangathirupathy, S; Sundaram, S; Singh, S; Sharma, S; Davis, JA; Chugh, A; Bansal, VS Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors. Bioorg Med Chem Lett18:4087-91 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 2 |
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| Name: | Dipeptidyl peptidase 2 |
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| Synonyms: | DAP II | DPP2 | DPP2_HUMAN | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 (DPP II) | Dipeptidyl peptidase 2 (DPP2) | Dipeptidyl peptidase II (DDP-II) | Dipeptidyl peptidase II (DPP II) | Dipeptidyl peptidase II (DPP2) | Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) | QPP | carboxytripeptidase | dipeptidyl arylamidase II | dipeptidyl(amino)peptidase II | dipeptidylarylamidase |
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| Type: | Protein |
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| Mol. Mass.: | 54339.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UHL4 |
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| Residue: | 492 |
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| Sequence: | MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
QPALRGGPRLSL
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| BDBM50251758 |
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| n/a |
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| Name | BDBM50251758 |
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| Synonyms: | (2S,4S)-1-(2-((1S,5R,6s)-3-(3-chloro-2-cyanophenyl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)-4-fluoropyrrolidine-2-carbonitrile | CHEMBL479538 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19ClFN5O |
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| Mol. Mass. | 387.838 |
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| SMILES | F[C@H]1C[C@@H](C#N)N(C1)C(=O)CN[C@@H]1[C@H]2CN(C[C@@H]12)c1cccc(Cl)c1C#N |r| |
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| Structure | 
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