| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aminopeptidase N |
|---|
| Ligand | BDBM50253340 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_511264 (CHEMBL996090) |
|---|
| IC50 | 168600±n/a nM |
|---|
| Citation |  Cheng, XC; Wang, Q; Fang, H; Tang, W; Xu, WF Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors. Bioorg Med Chem16:7932-8 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aminopeptidase N |
|---|
| Name: | Aminopeptidase N |
|---|
| Synonyms: | AMPN_HUMAN | ANPEP | APN | Alanyl aminopeptidase | Aminopeptidase | CD13 | CD_antigen=CD13 | Microsomal aminopeptidase | Myeloid plasma membrane glycoprotein CD13 | PEPN | gp150 | hAPN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 109522.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1507526 |
|---|
| Residue: | 967 |
|---|
| Sequence: | MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPA
SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVI
IIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDS
EFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP
KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI
RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLV
TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL
GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKG
ASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIM
NRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY
WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQ
IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKN
YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM
ENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI
LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN
LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ
WFTENSK
|
|
|
|---|
| BDBM50253340 |
|---|
| n/a |
|---|
| Name | BDBM50253340 |
|---|
| Synonyms: | 4-(3-Phenyl-acryloyloxy)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester | CHEMBL492881 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23NO6S |
|---|
| Mol. Mass. | 429.486 |
|---|
| SMILES | COC(=O)[C@@H]1C[C@H](CN1S(=O)(=O)c1ccc(C)cc1)OC(=O)\C=C\c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
