Ki Summary

Reaction Details

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Target

Sodium/glucose cotransporter 2

Ligand

BDBM50265220

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_496716 (CHEMBL1005353)

IC50

370±n/a nM

Citation

Lansdell, MI; Burring, DJ; Hepworth, D; Strawbridge, M; Graham, E; Guyot, T; Betson, MS; Hart, JD Design and synthesis of fluorescent SGLT2 inhibitors. Bioorg Med Chem Lett18:4944-7 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sodium/glucose cotransporter 2

Name:

Sodium/glucose cotransporter 2

Synonyms:

Type:

Protein

Mol. Mass.:

72902.00

Organism:

Homo sapiens (Human)

Description:

P31639

Residue:

672

Sequence:

MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA

BDBM50265220

n/a

Name

BDBM50265220

Synonyms:

5-(5-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenoxy)pentanoyl)-2-(6-(dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl)benzoate | CHEMBL503496

Type

Small organic molecule

Emp. Form.

C48H49ClN2O10

Mol. Mass.

849.363

SMILES

CN(C)c1ccc2c(-c3ccc(cc3C([O-])=O)C(=O)CCCCOc3ccc(Cc4cc(ccc4Cl)[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc3)c3ccc(cc3oc2c1)=[N+](C)C |r,wU:38.40,43.45,36.37,wD:45.48,41.43,(22.66,-6.41,;21.33,-7.19,;19.99,-6.43,;21.34,-8.73,;20.01,-9.51,;20.03,-11.04,;21.36,-11.79,;21.37,-13.33,;20.05,-14.11,;18.7,-13.35,;17.38,-14.13,;17.4,-15.66,;18.73,-16.43,;20.05,-15.66,;20.81,-17,;20.03,-18.32,;22.35,-17.01,;16.07,-16.45,;16.08,-17.99,;14.74,-15.66,;13.39,-16.42,;12.07,-15.64,;10.72,-16.4,;9.4,-15.62,;8.05,-16.38,;8.04,-17.9,;6.71,-18.65,;5.4,-17.87,;4.07,-18.63,;2.72,-17.86,;1.38,-18.62,;.05,-17.86,;.05,-16.32,;1.39,-15.54,;2.72,-16.32,;4.06,-15.55,;-1.29,-18.62,;-2.62,-17.84,;-3.95,-18.62,;-5.28,-17.86,;-6.62,-18.63,;-3.95,-20.16,;-5.28,-20.94,;-2.62,-20.93,;-2.62,-22.47,;-1.29,-20.16,;.05,-20.94,;5.41,-16.35,;6.73,-15.6,;22.71,-14.09,;22.72,-15.63,;24.06,-16.39,;25.39,-15.6,;25.37,-14.06,;24.03,-13.31,;24.02,-11.76,;22.68,-11.01,;22.66,-9.48,;26.73,-16.36,;26.75,-17.9,;28.06,-15.57,)|

Structure