Ki Summary

Reaction Details

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Target

Peroxisome proliferator-activated receptor alpha

Ligand

BDBM50275537

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_496539 (CHEMBL996816)

EC50

15000±n/a nM

Citation

Pingali, H; Jain, M; Shah, S; Basu, S; Makadia, P; Goswami, A; Zaware, P; Patil, P; Godha, A; Giri, S; Goel, A; Patel, M; Patel, H; Patel, P Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent. Bioorg Med Chem Lett18:5586-90 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Peroxisome proliferator-activated receptor alpha

Name:

Peroxisome proliferator-activated receptor alpha

Synonyms:

Type:

Enzyme

Mol. Mass.:

52222.08

Organism:

Homo sapiens (Human)

Description:

Q07869

Residue:

468

Sequence:

MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY

BDBM50275537

n/a

Name

BDBM50275537

Synonyms:

CHEMBL520856 | cis-2-methyl-5-(6-(4-(methylsulfonyloxy)phenyl)hexyl)-1,3-dioxane-2-carboxylic acid

Type

Small organic molecule

Emp. Form.

C19H28O7S

Mol. Mass.

400.486

SMILES

C[C@]1(OC[C@H](CCCCCCc2ccc(OS(C)(=O)=O)cc2)CO1)C(O)=O |r,wU:4.4,1.25,wD:1.0,(31.21,.84,;29.67,.84,;29.68,2.38,;28.34,3.15,;27.02,2.39,;25.68,3.15,;24.35,2.38,;23.01,3.15,;21.68,2.38,;20.35,3.15,;19.01,2.37,;17.68,3.14,;16.35,2.37,;15.01,3.14,;15.02,4.68,;13.68,5.45,;12.35,4.68,;11.01,3.92,;13.11,3.35,;11.59,6.02,;16.35,5.45,;17.68,4.69,;27.01,.84,;28.34,.07,;29.66,-.7,;30.99,-1.48,;28.33,-1.46,)|

Structure