| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Secreted frizzled-related protein 1 |
|---|
| Ligand | BDBM50265500 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_560813 (CHEMBL1011781) |
|---|
| IC50 | 60±n/a nM |
|---|
| Citation |  Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem52:105-16 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Secreted frizzled-related protein 1 |
|---|
| Name: | Secreted frizzled-related protein 1 |
|---|
| Synonyms: | FRP | FRP1 | SARP2 | SFRP1 | SFRP1_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35404.91 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1363191 |
|---|
| Residue: | 314 |
|---|
| Sequence: | MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVD
IPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPV
CLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKP
QGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKK
KDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKK
MKNHECPTFQSVFK
|
|
|
|---|
| BDBM50265500 |
|---|
| n/a |
|---|
| Name | BDBM50265500 |
|---|
| Synonyms: | (S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluoromethyl)phenylsulfonamido)piperidine-1-carbonyl)pyrrolidine-1-carboxylate | CHEMBL449276 | tert-Butyl (2S)-2-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H34F3N3O7S2 |
|---|
| Mol. Mass. | 645.711 |
|---|
| SMILES | CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
