Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50257783 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_565967 (CHEMBL960863) |
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EC50 | 30±n/a nM |
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Citation | Owen, DR; Rodriguez-Lens, M; Corless, MD; Gaulier, SM; Horne, VA; Kinloch, RA; Maw, GN; Pearce, DW; Rees, H; Ringer, TJ; Ryckmans, T; Stammen, BL 2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology. Bioorg Med Chem Lett19:1702-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50257783 |
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n/a |
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Name | BDBM50257783 |
Synonyms: | CHEMBL493516 | N-(1-(4-aminopyridin-2-yl)piperidin-4-yl)-N-(pyridin-2-yl)cyclohexanecarboxamide |
Type | Small organic molecule |
Emp. Form. | C22H29N5O |
Mol. Mass. | 379.4986 |
SMILES | Nc1ccnc(c1)N1CCC(CC1)N(C(=O)C1CCCCC1)c1ccccn1 |
Structure |
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