| Reaction Details |
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 | Report a problem with these data |
| Target | Suppressor of tumorigenicity 14 protein |
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| Ligand | BDBM50257706 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_566047 (CHEMBL954312) |
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| Ki | 150±n/a nM |
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| Citation |  Schweinitz, A; Dönnecke, D; Ludwig, A; Steinmetzer, P; Schulze, A; Kotthaus, J; Wein, S; Clement, B; Steinmetzer, T Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors. Bioorg Med Chem Lett19:1960-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Suppressor of tumorigenicity 14 protein |
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| Name: | Suppressor of tumorigenicity 14 protein |
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| Synonyms: | Epithin | Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein | MT-SP1 | Membrane-type serine protease 1 | PRSS14 | Prostamin | SNC19 | ST14 | ST14_HUMAN | Serine protease TADG-15 | Suppressor of tumorigenicity 14 protein | Suppressor of tumorigenicity protein 14 | TADG15 |
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| Type: | Single-pass type II membrane protein |
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| Mol. Mass.: | 94769.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Y6 |
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| Residue: | 855 |
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| Sequence: | MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
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| BDBM50257706 |
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| n/a |
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| Name | BDBM50257706 |
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| Synonyms: | (S)-3-amino-N-(3-(N-(3-(3-carbamimidoylphenyl)-1-(4-(4-hydroxyphenyl)piperazin-1-yl)-1-oxopropan-2-yl)sulfamoyl)phenyl)propanamide | CHEMBL506479 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H35N7O5S |
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| Mol. Mass. | 593.697 |
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| SMILES | NCCC(=O)Nc1cccc(c1)S(=O)(=O)N[C@@H](Cc1cccc(c1)C(N)=N)C(=O)N1CCN(CC1)c1ccc(O)cc1 |r| |
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| Structure | 
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