| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 5 |
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| Ligand | BDBM50267760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_563647 (CHEMBL963382) |
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| IC50 | 12700±n/a nM |
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| Citation |  Gaisina, IN; Gallier, F; Ougolkov, AV; Kim, KH; Kurome, T; Guo, S; Holzle, D; Luchini, DN; Blond, SY; Billadeau, DD; Kozikowski, AP From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells. J Med Chem52:1853-63 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 5 |
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| Name: | Cyclin-dependent kinase 5 |
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| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33308.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 292 |
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| Sequence: | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
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| BDBM50267760 |
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| n/a |
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| Name | BDBM50267760 |
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| Synonyms: | 3-Benzofuran-3-yl-4-(7-methoxymethyl-1-methyl-1H-indol-3-yl)pyrrole-2,5-dione | CHEMBL491647 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18N2O4 |
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| Mol. Mass. | 386.4 |
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| SMILES | COCc1cccc2c(cn(C)c12)C1=C(C(=O)NC1=O)c1coc2ccccc12 |t:15| |
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| Structure | 
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