| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 5 |
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| Ligand | BDBM50267607 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_563646 (CHEMBL963381) |
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| IC50 | 1160±n/a nM |
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| Citation |  Gaisina, IN; Gallier, F; Ougolkov, AV; Kim, KH; Kurome, T; Guo, S; Holzle, D; Luchini, DN; Blond, SY; Billadeau, DD; Kozikowski, AP From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells. J Med Chem52:1853-63 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 5 |
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| Name: | Cyclin-dependent kinase 5 |
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| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33308.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 292 |
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| Sequence: | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
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| BDBM50267607 |
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| n/a |
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| Name | BDBM50267607 |
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| Synonyms: | 3-(5-Bromo-1-methyl-1H-indol-3-yl)-4-(6-hydroxymethylbenzofuran-3-yl)pyrrole-2,5-dione | CHEMBL489833 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15BrN2O4 |
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| Mol. Mass. | 451.27 |
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| SMILES | Cn1cc(C2=C(C(=O)NC2=O)c2coc3cc(CO)ccc23)c2cc(Br)ccc12 |t:4| |
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| Structure | 
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