Reaction Details |
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Target | DNA topoisomerase 1 |
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Ligand | BDBM50249691 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_498348 (CHEMBL1020203) |
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EC50 | 160±n/a nM |
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Citation | Sunami, S; Nishimura, T; Nishimura, I; Ito, S; Arakawa, H; Ohkubo, M Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin. J Med Chem52:3225-37 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA topoisomerase 1 |
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Name: | DNA topoisomerase 1 |
Synonyms: | DNA topoisomerase I | TOP1_MOUSE | Top-1 | Top1 |
Type: | PROTEIN |
Mol. Mass.: | 90922.04 |
Organism: | Mus musculus |
Description: | ChEMBL_208411 |
Residue: | 767 |
Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSE
KKHKEKEKTKHKDGSSEKHKDKHKDRDKERRKEEKIRAAGDAKIKKEKENGFSSPPRIKD
EPEDDGYFAPPKEDIKPLKRLRDEDDADYKPKKIKTEDIKKEKKRKSEEEEDGKLKKPKN
KDKDKKVAEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESV
KFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLS
KCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPP
GLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTE
NIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVA
LYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYY
NKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITL
QQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQL
ADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGT
SKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF
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BDBM50249691 |
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n/a |
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Name | BDBM50249691 |
Synonyms: | 2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-2-yl]methyl}amino)-13-(beta-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione | CHEMBL446276 |
Type | Small organic molecule |
Emp. Form. | C33H29N5O11 |
Mol. Mass. | 671.6103 |
SMILES | OC[C@H]1O[C@@H](On2c3cc(O)ccc3c3c4C(=O)N(NCc5cc(CO)ccn5)C(=O)c4c4c5ccc(O)cc5[nH]c4c23)[C@H](O)[C@@H](O)[C@@H]1O |r| |
Structure |
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