Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Bifunctional epoxide hydrolase 2 |
---|
Ligand | BDBM50268439 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_523916 (CHEMBL1001509) |
---|
IC50 | 19±n/a nM |
---|
Citation | Shen, HC; Ding, FX; Wang, S; Xu, S; Chen, HS; Tong, X; Tong, V; Mitra, K; Kumar, S; Zhang, X; Chen, Y; Zhou, G; Pai, LY; Alonso-Galicia, M; Chen, X; Zhang, B; Tata, JR; Berger, JP; Colletti, SL Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett19:3398-404 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Bifunctional epoxide hydrolase 2 |
---|
Name: | Bifunctional epoxide hydrolase 2 |
Synonyms: | Ephx2 | Epoxide hydrolase 2 | HYES_RAT |
Type: | PROTEIN |
Mol. Mass.: | 62337.15 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1465995 |
Residue: | 554 |
Sequence: | MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
|
|
|
BDBM50268439 |
---|
n/a |
---|
Name | BDBM50268439 |
Synonyms: | (6-(methylsulfonyl)spiro[chroman-2,4'-piperidine]-1'-yl)(4-(trifluoromethyl)phenyl)methanone | CHEMBL497828 |
Type | Small organic molecule |
Emp. Form. | C22H22F3NO4S |
Mol. Mass. | 453.475 |
SMILES | CS(=O)(=O)c1ccc2OC3(CCN(CC3)C(=O)c3ccc(cc3)C(F)(F)F)CCc2c1 |
Structure |
|