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TargetBifunctional epoxide hydrolase 2
LigandBDBM50268441
Substrate/Competitorn/a
Meas. Tech.ChEMBL_523916 (CHEMBL1001509)
IC50 10±n/a nM
Citation Shen, HCDing, FXWang, SXu, SChen, HSTong, XTong, VMitra, KKumar, SZhang, XChen, YZhou, GPai, LYAlonso-Galicia, MChen, XZhang, BTata, JRBerger, JPColletti, SL Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett19:3398-404 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bifunctional epoxide hydrolase 2
Name:Bifunctional epoxide hydrolase 2
Synonyms:Ephx2 | Epoxide hydrolase 2 | HYES_RAT
Type:PROTEIN
Mol. Mass.:62337.15
Organism:Rattus norvegicus
Description:ChEMBL_1465995
Residue:554
Sequence:
MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
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  Blast E-value cutoff:
BDBM50268441
n/a
NameBDBM50268441
Synonyms:1-(6-fluorospiro[chroman-2,4'-piperidine]-1'-yl)-3-phenylpropan-1-one | CHEMBL447085
TypeSmall organic molecule
Emp. Form.C22H24FNO2
Mol. Mass.353.4299
SMILESFc1ccc2OC3(CCN(CC3)C(=O)CCc3ccccc3)CCc2c1
Structure
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