Reaction Details |
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Target | Type-1 angiotensin II receptor A/B |
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Ligand | BDBM50283308 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_34964 (CHEMBL647886) |
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IC50 | 0.390000±n/a nM |
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Citation | Glinka, TW; de Laszlo, SE; Siegl, PK; Chang, RS; Kivlighn, SD; Schorn, TS; Faust, KA; Chen, TB; Zingaro, GJ; Lotti, VJ; Greenlee, WJ Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes. Bioorg Med Chem Lett4:2337-2342 (1994) Article |
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More Info.: | Get all data from this article, Assay Method |
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Type-1 angiotensin II receptor A/B |
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Name: | Type-1 angiotensin II receptor A/B |
Synonyms: | Angiotensin II receptor (AT-1) type-1 | Type-1A/Type-1B angiotensin II receptor |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 901964 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Type-1 angiotensin II receptor B |
Synonyms: | AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40929.44 |
Organism: | RAT |
Description: | Angiotensin II AT1B 0 RAT::P29089 |
Residue: | 359 |
Sequence: | MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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Component 2 |
Name: | Type-1 angiotensin II receptor A |
Synonyms: | AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40910.53 |
Organism: | RAT |
Description: | ANGIOTENSIN AT1 AGTR1 RAT::P25095 |
Residue: | 359 |
Sequence: | MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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BDBM50283308 |
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n/a |
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Name | BDBM50283308 |
Synonyms: | 2-ethyl-3-(3-fluoro-2'-(3-methyl-but-2-enyloxycarbonylaminosulphonyl)-biphenyl-4-ylmethyl)-6-(N-isopropyl-N-methyl-aminocarbonylamino)-3H-quinazolin-4-one | CHEMBL76821 |
Type | Small organic molecule |
Emp. Form. | C34H38FN5O6S |
Mol. Mass. | 663.759 |
SMILES | [#6]-[#6]-c1nc2ccc(-[#7]-[#6](=O)-[#7](-[#6])-[#6](-[#6])-[#6])cc2c(=O)n1-[#6]-c1ccc(cc1F)-c1ccccc1S(=O)(=O)[#7]-[#6](=O)-[#8]-[#6]\[#6]=[#6](\[#6])-[#6] |
Structure |
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