| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C beta type |
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| Ligand | BDBM50285193 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_160609 |
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| IC50 | 270±n/a nM |
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| Citation |  Jirousek, MR; Gillig, JR; Neel, DA; Rito, CJ; O'Bannon, D; Heath, WF; McDonald, JH; Faul, MM; Winneroski, LL; Melikian-Badalian, A; Baevsky, M; Ballas, LM; Hall, SE Synthesis of bisindolylmaleimide macrocycles Bioorg Med Chem Lett5:2093-2096 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C beta type |
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| Name: | Protein kinase C beta type |
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| Synonyms: | KPCB_HUMAN | PKC alpha and beta-2 | PKC beta | PKC beta isoform 2 | PKCB | PRKCB | PRKCB1 | Protein Kinase C, beta II | Protein kinase C beta type | Protein kinase C beta type II (PRKCB2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76873.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells
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| Residue: | 671 |
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| Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
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| BDBM50285193 |
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| n/a |
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| Name | BDBM50285193 |
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| Synonyms: | 17-hydroxymethyl-18-oxa-4,14,22-triazahexacyclo[20.6.1.17,14.02,6.08,13.023,28]triaconta-1(29),2(6),7(30),8(13),9,11,23(28),24,26-nonaene-3,5-dione | CHEMBL294120 | LY-317644 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25N3O4 |
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| Mol. Mass. | 455.5051 |
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| SMILES | OCC1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCCO1)c1ccccc31)c1ccccc21 |t:8| |
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| Structure | 
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