| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50031783 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_101897 |
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| Ki | 2270±n/a nM |
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| Citation |  Tomczuk, BE; Gowravaram, MR; Johnson, JS; Delecki, D; Cook, ER; Ghose, AK; Mathiowetz, AM; Spurlino, JC; Rubin, B; Smith, DL; Pulvino, T; Wahl, RC Hydroxamate inhibitors of the matrix metallo-proteinases (MMPs) containing novel P1′ heteroatom based modifications Bioorg Med Chem Lett5:343-348 (1995) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50031783 |
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| n/a |
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| Name | BDBM50031783 |
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| Synonyms: | (R)-2-(3-(benzyloxy)propyl)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)succinamide | (R)-2-(3-Benzyloxy-propyl)-N*4*-hydroxy-N*1*-((S)-1-methylcarbamoyl-2-phenyl-ethyl)-succinamide | CHEMBL313483 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N3O5 |
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| Mol. Mass. | 441.52 |
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| SMILES | CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCOCc1ccccc1)CC(=O)NO |
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| Structure | 
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