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TargetGastrin/cholecystokinin type B receptor
LigandBDBM50287260
Substrate/Competitorn/a
Meas. Tech.ChEBML_48255
IC50 930±n/a nM
Citation Kawanishi, YIshihara, STsushima, TSeno, KMiyagoshi, MHagishita, SIshikawa, MShima, NShimamura, MIshihara, Y Synthesis and pharmacological evaluation of highly potent dual histamine H2 and gastrin receptor antagonists Bioorg Med Chem Lett6:1427-1430 (1996)    Article
More Info.:Get all data from this article,  Assay Method
 
Gastrin/cholecystokinin type B receptor
Name:Gastrin/cholecystokinin type B receptor
Synonyms:Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:49196.59
Organism:MOUSE
Description:Cholecystokinin A CCKBR MOUSE::P56481
Residue:453
Sequence:
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGL
ISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCY
VQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANT
WRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
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  Blast E-value cutoff:
BDBM50287260
n/a
NameBDBM50287260
Synonyms:(3-{2-[2-(2,2-Diamino-vinyl)-thiazol-4-ylmethylsulfanyl]-ethylcarbamoyl}-propyl)-carbamic acid 2-[(R)-2-oxo-5-phenyl-3-(3-m-tolyl-ureido)-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-ethyl ester | CHEMBL282175
TypeSmall organic molecule
Emp. Form.C38H43N9O5S2
Mol. Mass.769.935
SMILESCc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CCOC(=O)NCCCC(=O)NCCSCc3csc(CC(N)=N)n3)C2=O)c1 |t:11|
Structure
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