| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50290159 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_106441 |
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| Ki | >50000±n/a nM |
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| Citation |  Decicco, CP; Seng, JL; Kennedy, KE; Covington, MB; Welch, PK; Arner, EC; Magolda, RL; Nelson, DJ Amide surrogates of matrix metalloproteinase inhibitors: Urea and sulfonamide mimics Bioorg Med Chem Lett7:2331-2336 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50290159 |
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| n/a |
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| Name | BDBM50290159 |
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| Synonyms: | 3-[(S)-2-(4-Methoxy-phenyl)-1-methylcarbamoyl-ethylsulfamoyl]-5-methyl-hexanoic acid | CHEMBL309794 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H28N2O6S |
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| Mol. Mass. | 400.49 |
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| SMILES | CNC(=O)[C@H](Cc1ccc(OC)cc1)NS(=O)(=O)C(CC(C)C)CC(O)=O |
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| Structure | 
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