Reaction Details |
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Target | Endothelin receptor type B |
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Ligand | BDBM50290951 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63875 |
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IC50 | 4500±n/a nM |
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Citation | Dorsch, D; Mederski, WW; Osswald, M; Devant, RM; Schmitges, CJ; Christadler, M; Wilm, C Pyridazinones with a pendant acylsulfonamide moiety as endothelin receptor antagonists Bioorg Med Chem Lett7:275-280 (1997) Article |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin receptor type B |
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Name: | Endothelin receptor type B |
Synonyms: | EDNRB | EDNRB_PIG | Endothelin receptor ET-B |
Type: | PROTEIN |
Mol. Mass.: | 49616.89 |
Organism: | Sus scrofa |
Description: | ChEMBL_63872 |
Residue: | 443 |
Sequence: | MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSN
ASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGN
STLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPF
IQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALG
FDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCE
MLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCE
LLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQS
CLKFKANDHGYDNFRSSNKYSSS
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BDBM50290951 |
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n/a |
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Name | BDBM50290951 |
Synonyms: | CHEMBL96847 | N-[2-Benzo[1,3]dioxol-5-yl-2-(5-methyl-6-oxo-3-propyl-6H-pyridazin-1-yl)-acetyl]-4-isopropyl-benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C26H29N3O6S |
Mol. Mass. | 511.59 |
SMILES | CCCc1cc(C)c(=O)n(n1)C(C(=O)NS(=O)(=O)c1ccc(cc1)C(C)C)c1ccc2OCOc2c1 |
Structure |
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