| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 2 |
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| Ligand | BDBM50291679 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106207 (CHEMBL872681) |
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| IC50 | 43000±n/a nM |
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| Citation |  Ma, D; Tian, H; Sun, H; Kozikowshi, AP; Pshenichkin, S; Wroblewski, JT Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists Bioorg Med Chem Lett7:1195-1198 (1997) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 2 |
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| Name: | Metabotropic glutamate receptor 2 |
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| Synonyms: | GRM2_RAT | Gprc1b | Grm2 | Mglur2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95786.41 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_105034 |
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| Residue: | 872 |
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| Sequence: | MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGAL
ESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAP
RASANLGQGSGSQFVPTVCNGREVVDSTTSSL
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| BDBM50291679 |
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| n/a |
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| Name | BDBM50291679 |
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| Synonyms: | 4-Amino-2,2-dimethyl-chroman-4,7-dicarboxylic acid | CHEMBL278949 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15NO5 |
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| Mol. Mass. | 265.2619 |
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| SMILES | CC1(C)CC(N)(C(O)=O)c2ccc(cc2O1)C(O)=O |
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| Structure | 
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