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TargetCytochrome P450 2D6
LigandBDBM50269061
Substrate/Competitorn/a
Meas. Tech.ChEMBL_577702 (CHEMBL1063962)
IC50 160±n/a nM
Citation Gudmundsson, KS; Boggs, SD; Sebahar, PR; Richardson, LD; Spaltenstein, A; Golden, P; Sethna, PB; Brown, KW; Moniri, K; Harvey, R; Romines, KR Tetrahydrocarbazole amides with potent activity against human papillomaviruses. Bioorg Med Chem Lett19:4110-4 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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  Blast E-value cutoff:
BDBM50269061
n/a
NameBDBM50269061
Synonyms:(1R)-6-Bromo-N-[(1R)-1-phenylethyl]-2,3,4,9-tetrahydro-1H-carbazole-1-amine | (R)-6-bromo-N-((R)-1-phenylethyl)-2,3,4,9-tetrahydro-1H-carbazol-1-amine | CHEMBL508368
TypeSmall organic molecule
Emp. Form.C20H21BrN2
Mol. Mass.369.298
SMILESC[C@@H](N[C@@H]1CCCc2c1[nH]c1ccc(Br)cc21)c1ccccc1 |r|
Structure
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