| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM50296374 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_580552 (CHEMBL1053998) |
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| IC50 | 353.7±n/a nM |
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| Citation |  Lakshminarayana, N; Rajendra Prasad, Y; Gharat, L; Thomas, A; Ravikumar, P; Narayanan, S; Srinivasan, CV; Gopalan, B Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents. Eur J Med Chem44:3147-57 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM50296374 |
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| n/a |
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| Name | BDBM50296374 |
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| Synonyms: | (3S)-7-[2-(2,2-Dimethyl-1,3-dithiolan-4-yl)ethylcarboxamido]-isochroman-3-carboxylic acid | CHEMBL549372 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23NO4S2 |
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| Mol. Mass. | 381.51 |
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| SMILES | CC1(C)SCC(CCC(=O)Nc2ccc3C[C@H](OCc3c2)C(O)=O)S1 |r| |
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| Structure | 
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