| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
|---|
| Ligand | BDBM50297412 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_582788 (CHEMBL1058192) |
|---|
| IC50 | 6±n/a nM |
|---|
| Citation |  Eldrup, AB; Soleymanzadeh, F; Taylor, SJ; Muegge, I; Farrow, NA; Joseph, D; McKellop, K; Man, CC; Kukulka, A; De Lombaert, S Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem52:5880-95 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bifunctional epoxide hydrolase 2 |
|---|
| Name: | Bifunctional epoxide hydrolase 2 |
|---|
| Synonyms: | Ephx2 | Epoxide hydrolase 2 | HYES_RAT |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 62337.15 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1465995 |
|---|
| Residue: | 554 |
|---|
| Sequence: | MALRVAAFDLDGVLALPSIAGVLRHTEEALALPRDFLLGAFQMKFPEGPTEQLMKGKITF
SQWVPLMDESCRKSSKACGASLPENFSISEIFSQAMAARSINRPMLQAAAALKKKGFTTC
IVTNNWLDDSDKRDILAQMMCELSQHFDFLIESCQVGMIKPEPQIYKFVLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVRDTASALRELEKVTGTQFPEAPLPVPCSPNDVSHGYV
TVKPGIRLHFVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCEEMVTFLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPL
MPPNPEVSPMEVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNK
ATEMGGILVGTPEDPKVSKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSCKALG
RKILVPALMVTAEKDIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQILIKW
LKTEIQNPSVTSKI
|
|
|
|---|
| BDBM50297412 |
|---|
| n/a |
|---|
| Name | BDBM50297412 |
|---|
| Synonyms: | CHEMBL560740 | N-[3,3-Bis-(4-fluorophenyl)-propyl]-6-(2,2,2-trifluoro-ethoxy)-nicotinamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H19F5N2O2 |
|---|
| Mol. Mass. | 450.4012 |
|---|
| SMILES | Fc1ccc(cc1)C(CCNC(=O)c1ccc(OCC(F)(F)F)nc1)c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
