| Reaction Details |
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 | Report a problem with these data |
| Target | Elongation of very long chain fatty acids protein 5 |
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| Ligand | BDBM50299971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_592861 (CHEMBL1045804) |
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| IC50 | >1E4±n/a nM |
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| Citation |  Mizutani, T; Ishikawa, S; Nagase, T; Takahashi, H; Fujimura, T; Sasaki, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors. J Med Chem52:7289-300 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Elongation of very long chain fatty acids protein 5 |
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| Name: | Elongation of very long chain fatty acids protein 5 |
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| Synonyms: | ELOV5_HUMAN | ELOVL2 | ELOVL5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35313.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_572243 |
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| Residue: | 299 |
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| Sequence: | MEHFDASLSTYFKALLGPRDTRVKGWFLLDNYIPTFICSVIYLLIVWLGPKYMRNKQPFS
CRGILVVYNLGLTLLSLYMFCELVTGVWEGKYNFFCQGTRTAGESDMKIIRVLWWYYFSK
LIEFMDTFFFILRKNNHQITVLHVYHHASMLNIWWFVMNWVPCGHSYFGATLNSFIHVLM
YSYYGLSSVPSMRPYLWWKKYITQGQLLQFVLTIIQTSCGVIWPCTFPLGWLYFQIGYMI
SLIALFTNFYIQTYNKKGASRRKDHLKDHQNGSMAAVNGHTNSFSPLENNVKPRKLRKD
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| BDBM50299971 |
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| n/a |
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| Name | BDBM50299971 |
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| Synonyms: | 4-Fluoro-N-{[(+)-(4S)-2-oxo-6-(1H-pyrazol-5-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}benzamide | CHEMBL570571 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14F4N4O3 |
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| Mol. Mass. | 434.3438 |
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| SMILES | Fc1ccc(cc1)C(=O)NC[C@]1(OC(=O)Nc2ccc(cc12)-c1cc[nH]n1)C(F)(F)F |r| |
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| Structure | 
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