Reaction Details |
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Target | Sodium-dependent noradrenaline transporter |
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Ligand | BDBM50300519 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_592526 (CHEMBL1044082) |
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IC50 | 15±n/a nM |
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Citation | Mahaney, PE; Kim, CY; Coghlan, RD; Cohn, ST; Heffernan, GD; Huselton, CA; Terefenko, EA; Vu, AT; Zhang, P; Burroughs, KD; Cosmi, SA; Bray, JA; Johnston, GH; Deecher, DC; Trybulski, EJ Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors. Bioorg Med Chem Lett19:5807-10 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent noradrenaline transporter |
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Name: | Sodium-dependent noradrenaline transporter |
Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 69337.72 |
Organism: | Homo sapiens (Human) |
Description: | P23975 |
Residue: | 617 |
Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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BDBM50300519 |
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n/a |
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Name | BDBM50300519 |
Synonyms: | (1S,2R)-1-(3-fluorophenyl)-1-(4-methyl-1H-indol-1-yl)-3-(methylamino)propan-2-ol | CHEMBL574921 |
Type | Small organic molecule |
Emp. Form. | C19H21FN2O |
Mol. Mass. | 312.3812 |
SMILES | CNC[C@@H](O)[C@H](c1cccc(F)c1)n1ccc2c(C)cccc12 |r| |
Structure |
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