Reaction Details |
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Target | Cannabinoid receptor 1 |
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Ligand | BDBM50301737 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_597913 (CHEMBL1042698) |
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Ki | 38±n/a nM |
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Citation | Dow, RL; Hadcock, JR; Scott, DO; Schneider, SR; Paight, ES; Iredale, PA; Carpino, PA; Griffith, DA; Hammond, M; Dasilva-Jardine, P Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: potent, orally-active 1,4-disubstituted imidazoles. Bioorg Med Chem Lett19:5351-4 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cannabinoid receptor 1 |
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Name: | Cannabinoid receptor 1 |
Synonyms: | Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_RAT | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cnr1 | Skr6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52856.55 |
Organism: | Rattus norvegicus (rat) |
Description: | P20272 |
Residue: | 473 |
Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEENIQCGENFMDMECFMILNPSQQLAI
AVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHV
FHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCL
MWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILW
KAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPL
LAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTA
QPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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BDBM50301737 |
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n/a |
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Name | BDBM50301737 |
Synonyms: | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(5-ethyl-1-isopropyl-1H-imidazol-4-yl)-4-methyl-1H-pyrazole | CHEMBL568007 |
Type | Small organic molecule |
Emp. Form. | C24H23Cl3N4 |
Mol. Mass. | 473.825 |
SMILES | CCc1c(ncn1C(C)C)-c1nn(c(c1C)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl |
Structure |
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