| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fructose-1,6-bisphosphatase 1 |
|---|
| Ligand | BDBM50303860 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_595157 (CHEMBL1037322) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Dang, Q; Kasibhatla, SR; Xiao, W; Liu, Y; Dare, J; Taplin, F; Reddy, KR; Scarlato, GR; Gibson, T; van Poelje, PD; Potter, SC; Erion, MD Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics. J Med Chem53:441-51 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fructose-1,6-bisphosphatase 1 |
|---|
| Name: | Fructose-1,6-bisphosphatase 1 |
|---|
| Synonyms: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36843.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Liver FBPase (P09467) |
|---|
| Residue: | 338 |
|---|
| Sequence: | MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
|
|
|
|---|
| BDBM50303860 |
|---|
| n/a |
|---|
| Name | BDBM50303860 |
|---|
| Synonyms: | 4-Amino-5-fluoro-1-isobutyl-2-[5-(2-phosphono)furanyl]benzimidazole | CHEMBL585945 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H17FN3O4P |
|---|
| Mol. Mass. | 353.2853 |
|---|
| SMILES | CC(C)Cn1c(nc2c(N)c(F)ccc12)-c1ccc(o1)P(O)(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
