| Reaction Details |
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 | Report a problem with these data |
| Target | Fructose-1,6-bisphosphatase 1 |
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| Ligand | BDBM50303854 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_595158 (CHEMBL1037323) |
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| IC50 | 550±n/a nM |
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| Citation |  Dang, Q; Kasibhatla, SR; Xiao, W; Liu, Y; Dare, J; Taplin, F; Reddy, KR; Scarlato, GR; Gibson, T; van Poelje, PD; Potter, SC; Erion, MD Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics. J Med Chem53:441-51 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fructose-1,6-bisphosphatase 1 |
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| Name: | Fructose-1,6-bisphosphatase 1 |
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| Synonyms: | F16P1_RAT | Fbp | Fbp1 | Fructose-1,6-bisphosphatase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39605.40 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_595158 |
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| Residue: | 363 |
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| Sequence: | MVDHAPFETDISTLTRFVLEEGRKAGGTGEMTQLLNSLCTAIKAISSAVRQAGIAQLYGI
AGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEEDTHAIIIEPEKRGKYVVCFDP
LDGSSNIDCLASIGTIFGIYRKTSANEPSEKDALQPGRNLVAAGYALYGSATMLVLAMNC
GVNCFMLDPSIGEFILVDRDVKIKKKGNIYSINEGYAKDFDPAINEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKNPSGKLRLLYECNPIAYVMEKAGGLATTGN
EDILDIVPTEIHQKAPVIMGSTEDVQEFLEIYNKDKAKSRPSLPLPQSRARESPVHSICD
ELF
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| BDBM50303854 |
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| n/a |
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| Name | BDBM50303854 |
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| Synonyms: | 5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]imidazol-2-yl)furan-2-ylphosphonic acid | CHEMBL570790 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H21FN3O4P |
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| Mol. Mass. | 381.3385 |
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| SMILES | CCc1cc(F)c(N)c2nc(-c3ccc(o3)P(O)(O)=O)n(CC(C)C)c12 |
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| Structure | 
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