| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stearoyl-CoA desaturase |
|---|
| Ligand | BDBM50304938 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_606659 (CHEMBL1071886) |
|---|
| IC50 | 250±n/a nM |
|---|
| Citation |  Uto, Y; Ogata, T; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Deguchi, T; Watanabe, N; Konishi, M; Okuyama, R; Kurikawa, N; Takagi, T; Wakimoto, S; Ohsumi, J Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats. Bioorg Med Chem Lett20:341-5 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stearoyl-CoA desaturase |
|---|
| Name: | Stearoyl-CoA desaturase |
|---|
| Synonyms: | Acyl-CoA desaturase | FADS5 | SCD | SCD1 | SCDOS | SCD_HUMAN | Stearoyl-CoA (SCD1) | Stearoyl-CoA desaturase 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41537.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00767 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYK
DKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAH
RLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFS
HVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGE
TFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNY
HHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG
|
|
|
|---|
| BDBM50304938 |
|---|
| n/a |
|---|
| Name | BDBM50304938 |
|---|
| Synonyms: | CHEMBL590592 | N-phenethyl-5-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)picolinamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25F3N4O2 |
|---|
| Mol. Mass. | 482.4975 |
|---|
| SMILES | FC(F)(F)c1ccccc1C(=O)N1CCN(CC1)c1ccc(nc1)C(=O)NCCc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
