Reaction Details |
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Target | Acyl-CoA desaturase 1 |
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Ligand | BDBM50306124 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_606059 (CHEMBL1071958) |
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IC50 | 0.6±n/a nM |
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Citation | Uto, Y; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Ogata, T; Deguchi, T; Yamada, M; Watanabe, N; Konishi, M; Kurikawa, N; Takagi, T; Wakimoto, S; Kono, K; Ohsumi, J Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine]. Bioorg Med Chem Lett20:746-54 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acyl-CoA desaturase 1 |
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Name: | Acyl-CoA desaturase 1 |
Synonyms: | ACOD1_MOUSE | Scd1 |
Type: | PROTEIN |
Mol. Mass.: | 41064.54 |
Organism: | Mus musculus |
Description: | ChEMBL_1462109 |
Residue: | 355 |
Sequence: | MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEG
PPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWS
HRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGW
LLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVN
SLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTF
PFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
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BDBM50306124 |
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n/a |
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Name | BDBM50306124 |
Synonyms: | 6-(5-chlorospiro[chroman-2,4'-piperidine]-1'-yl)-N-(2-hydroxy-2-(pyridin-3-yl)ethyl)pyridazine-3-carboxamide | CHEMBL595254 |
Type | Small organic molecule |
Emp. Form. | C25H26ClN5O3 |
Mol. Mass. | 479.959 |
SMILES | OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CCc1c(Cl)cccc1O2)c1cccnc1 |
Structure |
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