| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 1 |
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| Ligand | BDBM50308525 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_613465 (CHEMBL1070173) |
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| IC50 | 39000±n/a nM |
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| Citation |  Arai, H; Hirasawa, Y; Rahman, A; Kusumawati, I; Zaini, NC; Sato, S; Aoyama, C; Takeo, J; Morita, H Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem18:2152-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/glucose cotransporter 1 |
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| Name: | Sodium/glucose cotransporter 1 |
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| Synonyms: | High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1 |
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| Type: | Protein |
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| Mol. Mass.: | 73503.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P13866 |
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| Residue: | 664 |
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| Sequence: | MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
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| BDBM50308525 |
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| n/a |
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| Name | BDBM50308525 |
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| Synonyms: | Alstiphyllanine F | CHEMBL592521 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H36N2O9 |
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| Mol. Mass. | 592.6362 |
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| SMILES | COC(=O)[C@]1(COC(=O)c2cc(OC)c(OC)c(OC)c2)[C@H]2C[C@@H]3N(C\C2=C\C)[C@@H]2C[C@]11c4cc(OC)ccc4N[C@]31O2 |r| |
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| Structure | 
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