Reaction Details |
| Report a problem with these data |
Target | Dipeptidyl peptidase 1 |
---|
Ligand | BDBM50310704 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_621086 (CHEMBL1113170) |
---|
IC50 | 523±n/a nM |
---|
Citation | Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C. Bioorg Med Chem Lett19:5392-6 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dipeptidyl peptidase 1 |
---|
Name: | Dipeptidyl peptidase 1 |
Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
Type: | Enzyme |
Mol. Mass.: | 51857.28 |
Organism: | Homo sapiens (Human) |
Description: | P53634 |
Residue: | 463 |
Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
|
|
|
BDBM50310704 |
---|
n/a |
---|
Name | BDBM50310704 |
Synonyms: | CHEMBL1078356 | Cis-(2S,4S)-N-(2-benzyl-1-cyanocyclopropyl)-4-fluoropyrrolidine-2-carboxamide |
Type | Small organic molecule |
Emp. Form. | C16H18FN3O |
Mol. Mass. | 287.332 |
SMILES | F[C@@H]1CN[C@@H](C1)C(=O)NC1(CC1Cc1ccccc1)C#N |r| |
Structure |
|