Reaction Details |
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Target | Prostaglandin G/H synthase 1 |
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Ligand | BDBM50314584 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_625110 (CHEMBL1114348) |
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IC50 | 6000±n/a nM |
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Citation | Yu, G; Praveen Rao, PN; Chowdhury, MA; Abdellatif, KR; Dong, Y; Das, D; Velázquez, CA; Suresh, MR; Knaus, EE Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase. Bioorg Med Chem Lett20:2168-73 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 1 |
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Name: | Prostaglandin G/H synthase 1 |
Synonyms: | COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
Type: | Protein |
Mol. Mass.: | 68868.60 |
Organism: | Ovis aries (Sheep) |
Description: | n/a |
Residue: | 600 |
Sequence: | MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVR
SNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRR
FLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLML
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
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BDBM50314584 |
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n/a |
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Name | BDBM50314584 |
Synonyms: | (1-Difluoromethyl-2-oxo-1,2-dihydropyridin-3-yl)acetic acid | CHEMBL1089958 |
Type | Small organic molecule |
Emp. Form. | C8H7F2NO3 |
Mol. Mass. | 203.1429 |
SMILES | OC(=O)Cc1cccn(C(F)F)c1=O |
Structure |
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