| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50314656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_625597 (CHEMBL1110678) |
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| IC50 | 1.8±n/a nM |
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| Citation |  Chen, A; Bayly, C; Bezençon, O; Richard-Bildstein, S; Dubé, D; Dubé, L; Gagné, S; Gallant, M; Gaudreault, M; Grimm, E; Houle, R; Lacombe, P; Laliberté, S; Lévesque, JF; Liu, S; MacDonald, D; Mackay, B; Martin, D; McKay, D; Powell, D; Remen, L; Soisson, S; Toulmond, S Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension. Bioorg Med Chem Lett20:2204-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50314656 |
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| n/a |
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| Name | BDBM50314656 |
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| Synonyms: | 4-((3-amino-N-cyclopropyl-2-(4-(3-(2,6-dichloro-4-methylphenoxy)propyl)benzyl)propanamido)methyl)-5-chloro-2-(3-methoxypropyl)pyridine 1-oxide | CHEMBL1093936 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H40Cl3N3O4 |
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| Mol. Mass. | 649.047 |
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| SMILES | COCCCc1cc(CN(C2CC2)C(=O)C(CN)Cc2ccc(CCCOc3c(Cl)cc(C)cc3Cl)cc2)c(Cl)c[n+]1[O-] |
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| Structure | 
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