Reaction Details |
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Target | Renin |
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Ligand | BDBM50314660 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_625597 (CHEMBL1110678) |
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IC50 | 350±n/a nM |
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Citation | Chen, A; Bayly, C; Bezençon, O; Richard-Bildstein, S; Dubé, D; Dubé, L; Gagné, S; Gallant, M; Gaudreault, M; Grimm, E; Houle, R; Lacombe, P; Laliberté, S; Lévesque, JF; Liu, S; MacDonald, D; Mackay, B; Martin, D; McKay, D; Powell, D; Remen, L; Soisson, S; Toulmond, S Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension. Bioorg Med Chem Lett20:2204-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50314660 |
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n/a |
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Name | BDBM50314660 |
Synonyms: | 2-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)benzyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3-(methylamino)propanamide | CHEMBL1091040 |
Type | Small organic molecule |
Emp. Form. | C30H31Cl3F2N2O2 |
Mol. Mass. | 595.935 |
SMILES | CNCC(Cc1ccc(CCCOc2c(F)ccc(F)c2Cl)cc1)C(=O)N(Cc1cccc(Cl)c1Cl)C1CC1 |
Structure |
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