| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Deoxynucleoside kinase |
|---|
| Ligand | BDBM50314844 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_627484 (CHEMBL1111770) |
|---|
| IC50 | 2900±n/a nM |
|---|
| Citation |  Van Poecke, S; Negri, A; Gago, F; Van Daele, I; Solaroli, N; Karlsson, A; Balzarini, J; Van Calenbergh, S 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem53:2902-12 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Deoxynucleoside kinase |
|---|
| Name: | Deoxynucleoside kinase |
|---|
| Synonyms: | DNK_DROME | Deoxyribonucleoside kinase | Dm-dNK | Multispecific deoxynucleoside kinase | dnk |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 29092.93 |
|---|
| Organism: | Drosophila melanogaster |
|---|
| Description: | ChEMBL_627484 |
|---|
| Residue: | 250 |
|---|
| Sequence: | MAEAASCARKGTKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNV
NGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRR
NGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYL
QELHELHEDWLIHQRRPQSCKVLVLDADLNLENIGTEYQRSESSIFDAISSNQQPSPVLV
SPSKRQRVAR
|
|
|
|---|
| BDBM50314844 |
|---|
| n/a |
|---|
| Name | BDBM50314844 |
|---|
| Synonyms: | 3'-Deoxy-3'-(4-phenyl-1,2,3-triazol-1-yl)-beta-(E)-5-(2-bromovinyl)-2'-deoxyuridine | CHEMBL1091931 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18BrN5O4 |
|---|
| Mol. Mass. | 460.281 |
|---|
| SMILES | OC[C@H]1O[C@H](C[C@@H]1n1cc(nn1)-c1ccccc1)n1cc(C=CBr)c(=O)[nH]c1=O |r,w:22.25| |
|---|
| Structure | 
|
|---|
Search and Browse
