| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor 1 |
|---|
| Ligand | BDBM50002369 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_627998 (CHEMBL1105519) |
|---|
| EC50 | 73000±n/a nM |
|---|
| Citation |  Fleming, JJ; England, PM Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem18:1381-7 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor 1 |
|---|
| Name: | Glutamate receptor 1 |
|---|
| Synonyms: | AMPA-selective glutamate receptor 1 | GLUH1 | GLUR1 | GRIA1 | GRIA1_HUMAN | GluR-1 | GluR-A | GluR-K1 | Glutamate AMPA 1 | Glutamate receptor 1 | Glutamate receptor AMPA 1/2 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 101512.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Glutamate AMPA 1 GRIA1 HUMAN::P42261 |
|---|
| Residue: | 906 |
|---|
| Sequence: | MQHIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQID
IVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQ
FVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTT
TEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDL
NKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYTSALTYDGVKVM
AEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR
RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGE
LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW
MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ
QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA
YGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLES
TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKW
WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
GFCLIPQQSINEAIRTSTLPRNSGAGASSGGSGENGRVVSHDFPKSMQSIPCMSHSSGMP
LGATGL
|
|
|
|---|
| BDBM50002369 |
|---|
| n/a |
|---|
| Name | BDBM50002369 |
|---|
| Synonyms: | (2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid | (3S,4R)-3-(carboxymethyl)-4-(prop-1-en-2-yl)-L-proline | CHEMBL275040 | Digenin | Digensaeure | Helminal | Kainate | Kainsaeure | L-alpha-kainic acid | alpha-Kainic acid | digenic acid | kainic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H15NO4 |
|---|
| Mol. Mass. | 213.2304 |
|---|
| SMILES | CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
