| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
|---|
| Ligand | BDBM50318892 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_633683 (CHEMBL1118308) |
|---|
| EC50 | 2000±n/a nM |
|---|
| Citation |  Boatman, PD; Schrader, TO; Kasem, M; Johnson, BR; Skinner, PJ; Jung, JK; Xu, J; Cherrier, MC; Webb, PJ; Semple, G; Sage, CR; Knudsen, J; Chen, R; Taggart, AK; Carballo-Jane, E; Richman, JG Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a). Bioorg Med Chem Lett20:2797-800 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hydroxycarboxylic acid receptor 2 |
|---|
| Name: | Hydroxycarboxylic acid receptor 2 |
|---|
| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 41868.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
|---|
| Residue: | 363 |
|---|
| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
|
|
|
|---|
| BDBM50318892 |
|---|
| n/a |
|---|
| Name | BDBM50318892 |
|---|
| Synonyms: | (2'R,4'S)-7'-(1H-1,2,3,4-tetrazol-5-yl)-8',9'-diazaspiro[cyclopentane-1,3'-tricyclo[4.3.0.0^{2,4}]nonane]-1'(6'),7'-diene | CHEMBL1083990 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H14N6 |
|---|
| Mol. Mass. | 242.2798 |
|---|
| SMILES | C1CCC2(C1)[C@H]1Cc3c([nH]nc3-c3nnn[nH]3)[C@@H]21 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
