| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50325486 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_652205 (CHEMBL1228478) |
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| Ki | 6.3±n/a nM |
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| Citation |  Ting, PC; Lee, JF; Albanese, MM; Wu, J; Aslanian, R; Favreau, L; Nardo, C; Korfmacher, WA; West, RE; Williams, SM; Anthes, JC; Rivelli, MA; Corboz, MR; Hey, JA The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists. Bioorg Med Chem Lett20:5004-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48753.61 |
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| Organism: | GUINEA PIG |
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| Description: | HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAF
VADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCT
SSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSG
GSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGARE
AGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHSSLEHCWK
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| BDBM50325486 |
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| n/a |
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| Name | BDBM50325486 |
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| Synonyms: | (4-(3-chlorobenzyl)piperazin-1-yl)(1-(pyridin-4-ylmethyl)piperidin-4-yl)methanone | CHEMBL1223502 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29ClN4O |
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| Mol. Mass. | 412.956 |
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| SMILES | Clc1cccc(CN2CCN(CC2)C(=O)C2CCN(Cc3ccncc3)CC2)c1 |
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| Structure | 
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